(5.0) 1 review
Le Sérum Régénérant Intime

The Ultimate Vaginal Super Sérum

Made in Switzerland1.0 fl. oz. / 30 ml

A Swiss-engineered, nutrient-dense formulation that supports the vulvar skin barrier, helps maintain a balanced intimate microbiome, and delivers deep, sustained hydration.

Dermatologically suited for intimate skin. Clinically tested for sensitivity. Certified to maintain the Microbiome badge TM

 

  • Supports skin firmness and elasticity
  • Helps maintain a lactobacillus-favorable intimate environment
  • Supports lasting freshness and comfort
  • Hydrates, smoothes and softens
  • Biomimetically formulated to support the natural intimate ecosystem
  • Lightweight, silky, non-sticky
For sensitive skin
Maintains the microbiome

Key Ingredients

SWISS-CULTURED PLANT STEM CELLS
Supports the proteins that keep skin firm and elastic. Over time, skin feels stronger, smoother, and more resilient.

MICROFLORA FERMENT™️
A bio-fermented prebiotic and postbiotic complex that helps support a Lactobacillus-favorable intimate environment, promoting microbiome balance, a healthy acidic pH, and lasting freshness and comfort.

BIOMIMETIC RENEWAL COMPLEX®
Our proprietary blend of amino acids, peptides, cellular actives, and essential vitamins, developed through 22 years of Swiss biotechnology research. Clinically shown to support deep hydration, barrier strength, and visibly smoother, more resilient skin over time.

HYALURONIC ACID + GLYCOGEN
A dual-action hydration and microbiome complex powered by Swiss vegan glycogen, delivering deep, lasting hydration while supporting the Lactobacillus-balanced intimate microbiome.

Results over Time

100%
Felt hydration and freshness immediately after first use
92%
Reported reduced irritation and sensitivity
80%
Reported increased confidence in skin tone and texture
  • Apply 1–2 pumps to the vulva and surrounding external intimate skin. Use morning and evening as part of your daily skincare ritual, or as needed throughout the day for additional comfort and hydration. 
  • Restores healthy pH and lasting freshness
  • 200% increase in hydration after 1 hour
  • Supports collagen and elastin pathways for skin firmness
  • 6% increase in skin density after 28 days
  • 30% reduction in visible hyperpigmentation after 6 weeks

Based on Swiss clinical trials

Aqua, Propanediol, Aloe Barbadensis Leaf Juice, Potassium Sorbate, Sodium Benzoate, Xanthan Gum, Hydroxyethylcellulose, Sodium Hyaluronate, Lactobacillus Ferment Lysate, Glycerin, Avena Sativa (Oat) Meal Extract, Phenoxyethanol, Lycium Barbarum Callus Culture Extract, Isomalt, Lecithin, Glycogen, Lactic Acid

  • Alchohol
  • Fragrances
  • PEGs
  • Hormones
  • Surfactant
  • Phthalates
  • Fillers

Hydrate

Tighten

Brighten

Plump

Balance PH.

The science

A first of its kind intimate care serum engineered to biomimetically mimic the natural vaginal ecosystem, delivering lasting freshness, deep hydration, intimate skin firmness, microbiome balance, and optimal pH to support intimate health wellness.

Clinically Proven Results Over Time

Immediate

Phase 1
Rehydrate

Hydration · Soothing · Freshness

200% increase in hydration after one hour. Vulvar skin feels immediately soothed, calm, and fresh.

Within 1 Month of Daily Use

Phase 2 Rebalance

Balance · Strengthen · Protect

By week two, pH is restored. By week four, microbiome is rebalanced, symptoms are relieved, and skin barrier is strong and resilient.

Within 2 Months of Daily Use

Phase 3
Renew

Firm · Smooth · Tighten

By month 2, intimate skin appears firmer, smoother, brighter, and visibly revitalized for long term intimate wellness.

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Clinical Trial Results

0%

Felt hydration and freshness immediately after first use

0%

Said intimate skin looked visibly plumper

0%

Reported reduced discomfort, itching, and stinging

0%

Said intimate skin's elasticity felt good

0%

Said intimate skin felt firmer

0%

Reported increased confidence in appearance

Clinically tested on 25 women over 14 days, ages 25–50

LE SÉRUM SUPPORTS INTIMATE SKIN ACROSS ALL LIFE PHASES 

The Science

As estrogen naturally declines, the body produces less glycogen, hyaluronic acid, and collagen, key molecules involved in skin hydration, elasticity, and microbiome balance. Intimate skin can become thinner, drier, and more sensitive, with a weakened skin barrier that is more prone to irritation and discomfort.

How Le Sérum Helps

Our Hyaluronic Acid + Glycogen complex works to support the natural environment of intimate skin, while soothing botanicals including oat extract and aloe vera help calm dryness and sensitivity. Swiss-cultured plant stem cells support skin resilience and vitality, and Microflora Ferment helps maintain microbiome balance during hormonal transition.
78%

Menopausal women suffer vaginal dryness
(Source)

The Science

As skin ages, the natural production of hyaluronic acid and collagen gradually declines. Intimate skin, which is already thinner and more hormonally sensitive than facial skin, can become less firm, less elastic, and more prone to dryness over time.

How Le Sérum Helps

Swiss-cultured plant stem cells support collagen and elastin pathways, promoting skin firmness and resilience over time. Our Hyaluronic Acid + Glycogen complex delivers sustained hydration, leaving skin visibly smoother, plumper, and more even-looking with continued use.
50%

of women are dissatisfied with their intimate aesthetic
(Source)

The Science

Certain medications, including isotretinoin, GLP-1s, and SSRIs, can contribute to dryness in skin tissue and mucous membranes, leading to increased sensitivity, discomfort, and a weakened skin barrier.

How Le Sérum Helps

Clinically shown to increase hydration by 200% within one hour, Le Sérum delivers immediate and lasting hydration to sensitive intimate skin. Aloe vera, oat extract, and our Hyaluronic Acid + Glycogen complex work together to soothe discomfort and help support the skin's natural moisture balance.
73%

Suffer vaginal dryness after Accutane treatment

The Science

Hormonal fluctuations during and after pregnancy can affect skin elasticity, hydration levels, and microbiome balance. During the postpartum period, particularly while breastfeeding, reduced estrogen contributes to dryness, increased sensitivity, and a more vulnerable skin barrier.

How Le Sérum Helps

Our Biomimetic Renewal Complex®, Swiss-cultured plant stem cells, and Hyaluronic Acid + Glycogen work together to support skin barrier resilience during hormonal changes and deliver deep hydration to delicate skin. Microflora Ferment helps maintain microbiome balance of the external intimate skin, while soothing botanical extracts help ease dryness and sensitivity throughout recovery.
90%

Pregnant women experience hyperpigmentation and dryness

85%

Women who give birth suffer perineal trauma or tearing
(source)

65%

Women experience vaginal atrophy postpartum
(source)

The Science

The intimate microbiome is dynamic and sensitive, influenced daily by hormones, stress, medications, friction, and product use. When this balance is disrupted, the skin barrier can weaken, increasing the likelihood of dryness, irritation, and discomfort.

How Le Sérum Helps

Fragrance-free, alcohol-free, and pH-compatible, Le Sérum is formulated to support rather than disrupt the intimate microbiome. Our Microflora Ferment, a prebiotic and postbiotic complex, helps support a Lactobacillus-favorable environment, promoting microbiome balance and barrier resilience with continued use.
90%

Women suffer imbalanced vaginal microbiomes

The Science

The intimate area is one of the body's most hormonally sensitive regions. Friction, inflammation, hormonal fluctuations, and environmental stressors can gradually overstimulate melanin production, contributing to uneven skin tone over time.

How Le Sérum Helps

Swiss-cultured plant stem cells support skin vitality and resilience, while our Biomimetic Renewal Complex® works to improve overall skin quality and tone. With continued use, Le Sérum helps support brighter, more even-looking intimate skin.
90%

Hyperpigmentation cases occur in women. Hyperpigmentation of the intimate area is considered so prevalent that it affects almost everyone to some degree.

The power of our ingredients

Groundbreaking results validated in a series of Swiss clinical trials

increase in hyalauronic acid

0%

*in-vitro tested
reduction in hyper-pigmentation after 6 weeks

0%

tested on 13 volunteers, ages 25–60
Increase in Skin Density after 28 days

0%

tested on 23 women, aged 41-69
increase in hydratation after 1h

0%

*in-vitro tested
Increase in Collagen Production

0%

*in-vitro tested

Key ingredients

The Biomimetic
Renewal Complex®

Our proprietary blend of amino acids, peptides, cellular actives, and essential vitamins, developed through 22 years of Swiss biotechnology research. Clinically shown to support deep hydration, barrier strength, and visibly smoother, more resilient skin over time.

Swiss-Cultured
Plant Stem Cells

Supports the proteins that keep skin firm and elastic. Over time, skin feels stronger, smoother, and more resilient. 

Microflora
Ferment™

A bio-fermented prebiotic and postbiotic complex that helps support a Lactobacillus-favorable intimate environment, promoting microbiome balance, a healthy acidic pH, and lasting freshness and comfort.

HA + GLYCOGEN

A dual-action hydration and microbiome complex powered by Swiss vegan glycogen, delivering deep, lasting hydration while supporting the Lactobacillus-balanced intimate microbiome.

Oat Extract

Rich in soothing beta-glucans that help calm visible sensitivity, reinforce the skin barrier, and support lasting comfort. 

Aloe Vera

Provides immediate soothing hydration alongside antioxidant vitamins A, C, and E. Supports barrier lipids to help reduce visible dryness and redness. 

The Ultimate Vaginal Super Sérum

benefit
eau de nuit
le sérum
intimate
moisturizers
oral vaginal
probiotics
boric acid
douches
lasting freshness &
odor comfort
✓
masks;
temporary
limited
topical effect
temporary;
not for routine use
can disrupt balance
when overused
supports healthy
ph balance
✓
may disrupt
with fragrance or alcohol
limited
topical effect
acidifies;
not designed for daily use
can disrupt
when overused
supports microbiome
balance
✓
may disrupt
with fragrance or alcohol
✓ internal only
X
can disrupt
when overused
strengthens skin
barrier
✓
limited
X
may increase sensitivity
with overuse
X
smooths, firms &
supports elasticity
✓
X
X
X
X

EXPERIENCE A GROUNDBREAKING SOLUTION FOR INTIMATE HEALTH

customer reviews

What others say about
The Ultimate Vaginal Super Serum

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5.0
★ ★ ★ ★ ★

4 Customer Reviews

Write a review
Lillia M.
Verified buyer
★★★★★

“SO impressed by how hydrating and plumping this is. Absolutely LOVE this product.”

Serena K.
Verified buyer
★★★★★

“I can confidently say that the Eau de Nuit line brings attention to an area of self-care that deserves more openness, comfort, and celebration. This product is a daily essential to my routine that brings me lasting hydration throughout the day. I feel more confident, more connected to myself, and proud to be part of a brand that’s redefining what feminine care looks and feels like.”

Nicole P.
Verified buyer
★★★★★

“I can’t get over how good Eau de Nuit is! Makes me feel so good and confident about myself. Also LOVE how I can keep it on my bedside table and no one can even tell!”

Hailey A.
Verified buyer
★★★★★

“Eau de Nuit has honestly been such an incredible addition to my self care routine! It is truly a one of a kind product and I would recommend it to anyone. I have had great results — could scream on the rooftops how much I recommend this product!”

Frequently Asked Questions

Le Sérum Régénérant Intime is Eau de Nuit's hero product, a first-of-its-kind intimate serum built on genuine biotech innovation. Our proprietary Biomimetic Renewal Complex®, developed from the ground up in Switzerland, brings cellular-level science to a part of the body that has long been overlooked by high-performance skincare. 

Le Sérum is for external use only. It is applied to the vulva and surrounding external intimate skin and is not intended for internal use. 

Most intimate care products are designed around hygiene or fragrance. Le Sérum works at a fundamentally different level, focusing on barrier support, microbiome compatibility, and skin vitality using the same scientific rigor applied to the most advanced facial serums. It is the first product to bring this depth of biotech innovation, including a biomimetic swiss vegan glycogen-based microbiome architecture, to intimate skincare.

Intimate skin is biologically distinct: thinner, more hormonally sensitive, and home to a delicate microbiome with a specific pH range that conventional skincare actives can disrupt. Formulating for this area requires a level of precision and specialization that standard facial or body products are simply not designed to provide.

We recommend consulting your healthcare provider before introducing any new skincare product during pregnancy or while breastfeeding, as a precaution. 

Yes. Le Sérum is formulated with intimate skin's inherent sensitivity in mind, free from fragrance, alcohol, and ingredients that can disrupt pH or compromise the microbiome, and tested for use on the body's most reactive skin.

Le Sérum is free from parabens, endocrine disruptors, and ingredients known to compromise the vaginal microbiome or pH balance. It is formulated with the precision expected of Swiss biotech: every ingredient is there for a reason.

Apply 1–2 pumps to the vulva and surrounding external intimate skin as part of your morning and evening skincare ritual. Consistent daily use delivers the most meaningful results, skin barrier support, microbiome balance, and hydration all improve progressively with continued use.